I use my optical mouse in my right and and for my left hand use a Nostromo n50 game pad. Seen here:

The way I have mine setup is I use the D-pad button directly under my thumb as a jump key, the other 3 directions used for radar zoom, the bottom right key as a fire button (still use the mouse button too) and all of the rest are quick-keys for things like lagstats and other commands.
So how about it? Anyone else?